Changes

              
    

          
          
        
        

            
f
1
{
f
1
{
            
2
  "age_type": [],
2
  "age_type": [],
            
3
  "author": "Edoardo Luca Vigan\u00f2",
3
  "author": "Edoardo Luca Vigan\u00f2",
            
4
  "author_email": "edoardo.vigano@marionegri.it",
4
  "author_email": "edoardo.vigano@marionegri.it",
            
5
  "category": [],
5
  "category": [],
            
6
  "cells_number": "",
6
  "cells_number": "",
            
7
  "content": [],
7
  "content": [],
            
8
  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
8
  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
            
9
  "culture_medium": [],
9
  "culture_medium": [],
            
10
  "dimension": [],
10
  "dimension": [],
            
11
  "experiment_date": "",
11
  "experiment_date": "",
            
12
  "groups": [],
12
  "groups": [],
            
13
  "id": "9c0d9822-0d03-4da6-b073-df74b253cec5",
13
  "id": "9c0d9822-0d03-4da6-b073-df74b253cec5",
            
14
  "isopen": false,
14
  "isopen": false,
            
15
  "license_id": "notspecified",
15
  "license_id": "notspecified",
            
16
  "license_title": "License not specified",
16
  "license_title": "License not specified",
            
17
  "maintainer": "",
17
  "maintainer": "",
            
18
  "maintainer_email": "",
18
  "maintainer_email": "",
            
19
  "metadata_created": "2024-10-25T12:59:16.286721",
19
  "metadata_created": "2024-10-25T12:59:16.286721",
            
n
20
  "metadata_modified": "2024-10-25T13:00:41.070218",
n
20
  "metadata_modified": "2024-10-25T13:00:42.888072",
            
21
  "model": [],
21
  "model": [],
            
22
  "name": "increased-myocardial-oxidative-stress",
22
  "name": "increased-myocardial-oxidative-stress",
            
23
  "notes": "[Mitochondrial complexes inhibition leading to left 
23
  "notes": "[Mitochondrial complexes inhibition leading to left 
            
24
ventricular function decrease via increased myocardial oxidative 
24
ventricular function decrease via increased myocardial oxidative 
            
25
stress]\r\n\r\nIn accordance with the events outlined in the linear 
25
stress]\r\n\r\nIn accordance with the events outlined in the linear 
            
26
AOP framework for cardiotoxicity developed in ALTERNATIVE project we 
26
AOP framework for cardiotoxicity developed in ALTERNATIVE project we 
            
27
collected data from biological assays providing information on the 
27
collected data from biological assays providing information on the 
            
28
potential toxic interactions between chemicals and specific biological 
28
potential toxic interactions between chemicals and specific biological 
            
29
targets. \r\n\r\nList of assays considered for evaluating chemicals 
29
targets. \r\n\r\nList of assays considered for evaluating chemicals 
            
30
regarding Mitochondrial complexes inhibition leading to left 
30
regarding Mitochondrial complexes inhibition leading to left 
            
31
ventricular function decrease via increased myocardial oxidative 
31
ventricular function decrease via increased myocardial oxidative 
            
32
stress:\r\nAPR HepG2 P-H2AX 24 h dn,  APR HepG2 P-H2AX 24 h up,  APR 
32
stress:\r\nAPR HepG2 P-H2AX 24 h dn,  APR HepG2 P-H2AX 24 h up,  APR 
            
33
HepG2 P-H2AX 72 h dn,  APR HepG2 P-H2AX 72 h up,  APR HepG2 
33
HepG2 P-H2AX 72 h dn,  APR HepG2 P-H2AX 72 h up,  APR HepG2 
            
34
StressKinase 24 h dn,  APR HepG2 StressKinase 24 h up,  APR HepG2 
34
StressKinase 24 h dn,  APR HepG2 StressKinase 24 h up,  APR HepG2 
            
35
StressKinase 72 h dn\r\n\r\nAOP source: 
35
StressKinase 72 h dn\r\n\r\nAOP source: 
            
36
https://aopwiki.org/aops/479\r\npaper: 
36
https://aopwiki.org/aops/479\r\npaper: 
            
37
https://doi.org/10.3390/toxics12010087",
37
https://doi.org/10.3390/toxics12010087",
            
38
  "num_resources": 1,
38
  "num_resources": 1,
            
39
  "num_tags": 2,
39
  "num_tags": 2,
            
40
  "organization": {
40
  "organization": {
            
41
    "approval_status": "approved",
41
    "approval_status": "approved",
            
42
    "created": "2023-03-17T17:42:44.917090",
42
    "created": "2023-03-17T17:42:44.917090",
            
43
    "description": "The Mario Negri Institute for Pharmacological 
43
    "description": "The Mario Negri Institute for Pharmacological 
            
44
Research (www.marionegri.it) is a not-for-profit 
44
Research (www.marionegri.it) is a not-for-profit 
            
45
biomedical\r\nresearch organization.\r\nIt was established in Milan in 
45
biomedical\r\nresearch organization.\r\nIt was established in Milan in 
            
46
1961 and later (1984) opened research units in Bergamo, currently 
46
1961 and later (1984) opened research units in Bergamo, currently 
            
47
located at the\r\nKilometro Rosso Science and Technology Park, and 
47
located at the\r\nKilometro Rosso Science and Technology Park, and 
            
48
Ranica (near Bergamo)",
48
Ranica (near Bergamo)",
            
49
    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
49
    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
50
    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
50
    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
            
51
    "is_organization": true,
51
    "is_organization": true,
            
52
    "name": "irfmn",
52
    "name": "irfmn",
            
53
    "state": "active",
53
    "state": "active",
            
54
    "title": "IRFMN",
54
    "title": "IRFMN",
            
55
    "type": "organization"
55
    "type": "organization"
            
56
  },
56
  },
            
57
  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
57
  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
58
  "private": false,
58
  "private": false,
            
59
  "ratio_hipsccms_hcaecs": "",
59
  "ratio_hipsccms_hcaecs": "",
            
60
  "relationships_as_object": [],
60
  "relationships_as_object": [],
            
61
  "relationships_as_subject": [],
61
  "relationships_as_subject": [],
            
62
  "replicates_number": "",
62
  "replicates_number": "",
            
63
  "resources": [
63
  "resources": [
            
64
    {
64
    {
            
65
      "cache_last_updated": null,
65
      "cache_last_updated": null,
            
66
      "cache_url": null,
66
      "cache_url": null,
            
67
      "created": "2024-10-25T13:00:41.137083",
67
      "created": "2024-10-25T13:00:41.137083",
            
68
      "datastore_active": false,
68
      "datastore_active": false,
            
69
      "description": "QSAR-ready dataset for Mitochondrial complexes 
69
      "description": "QSAR-ready dataset for Mitochondrial complexes 
            
70
inhibition leading to left ventricular function decrease via increased 
70
inhibition leading to left ventricular function decrease via increased 
            
71
myocardial oxidative stress\r\n\r\nlabels: Binary endpoint",
71
myocardial oxidative stress\r\n\r\nlabels: Binary endpoint",
            
72
      "format": "CSV",
72
      "format": "CSV",
            
73
      "hash": "",
73
      "hash": "",
            
74
      "id": "94dd3d13-992a-49c2-9fc4-37fde88b781d",
74
      "id": "94dd3d13-992a-49c2-9fc4-37fde88b781d",
            
75
      "last_modified": "2024-10-25T13:00:41.046658",
75
      "last_modified": "2024-10-25T13:00:41.046658",
            
n
76
      "metadata_modified": "2024-10-25T13:00:41.076663",
n
76
      "metadata_modified": "2024-10-25T13:00:42.933450",
            
77
      "mimetype": null,
77
      "mimetype": null,
            
78
      "mimetype_inner": null,
78
      "mimetype_inner": null,
            
79
      "name": "OxidativeStress_dataset_CDDD.csv",
79
      "name": "OxidativeStress_dataset_CDDD.csv",
            
80
      "package_id": "9c0d9822-0d03-4da6-b073-df74b253cec5",
80
      "package_id": "9c0d9822-0d03-4da6-b073-df74b253cec5",
            
81
      "position": 0,
81
      "position": 0,
            
82
      "resource_type": null,
82
      "resource_type": null,
            
83
      "size": 3702777,
83
      "size": 3702777,
            
84
      "state": "active",
84
      "state": "active",
            
85
      "url": 
85
      "url": 
            
86
92a-49c2-9fc4-37fde88b781d/download/oxidativestress_dataset_cddd.csv",
86
92a-49c2-9fc4-37fde88b781d/download/oxidativestress_dataset_cddd.csv",
            
87
      "url_type": "upload"
87
      "url_type": "upload"
            
88
    }
88
    }
            
89
  ],
89
  ],
            
90
  "size": 3702777,
90
  "size": 3702777,
            
t
91
  "state": "draft",
t
91
  "state": "active",
            
92
  "tags": [
92
  "tags": [
            
93
    {
93
    {
            
94
      "display_name": "IncreaseOxidativeStress",
94
      "display_name": "IncreaseOxidativeStress",
            
95
      "id": "5f87cf59-de95-445d-897e-8d8146d0aac6",
95
      "id": "5f87cf59-de95-445d-897e-8d8146d0aac6",
            
96
      "name": "IncreaseOxidativeStress",
96
      "name": "IncreaseOxidativeStress",
            
97
      "state": "active",
97
      "state": "active",
            
98
      "vocabulary_id": null
98
      "vocabulary_id": null
            
99
    },
99
    },
            
100
    {
100
    {
            
101
      "display_name": "cardiotoxicity",
101
      "display_name": "cardiotoxicity",
            
102
      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
102
      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
            
103
      "name": "cardiotoxicity",
103
      "name": "cardiotoxicity",
            
104
      "state": "active",
104
      "state": "active",
            
105
      "vocabulary_id": null
105
      "vocabulary_id": null
            
106
    }
106
    }
            
107
  ],
107
  ],
            
108
  "title": "Increased myocardial oxidative stress",
108
  "title": "Increased myocardial oxidative stress",
            
109
  "toxin": [],
109
  "toxin": [],
            
110
  "type": "dataset",
110
  "type": "dataset",
            
111
  "url": "",
111
  "url": "",
            
112
  "version": "0.2"
112
  "version": "0.2"
            
113
}
113
}