6 datasets found

Drug-induced cardiotoxicity (DICT). By utilizing labeling documents for FDA (U.S. Food and Drug Administration)-approved drugs, is developed the largest dataset of drugs...

Aryl Hydrocarbon Receptor Activation Data: The Target ID (CHEMBL3201) is assigned to Aryl Hydrocarbon Receptor (AHR) activation, so we collected all data related to this...

[Mitochondrial complexes inhibition leading to heart failure via decreased ATP production] In accordance with the events outlined in the linear AOP framework for cardiotoxicity...

hERG channel blockade leading to sudden cardiac death Increased mortality triggered by drug-mediated blockade of human ether-a-gogo-related gene (hERG) channel. The inhibition...

[Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress] In accordance with the events outlined in the linear...

Increase Mitochondrial Dysfunction In accordance with the events outlined in the linear AOP framework for cardiotoxicity developed in the ALTERNATIVE project, we collected data...