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{
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{
            
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  "age_type": [],
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  "age_type": [],
            
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  "author": "Edoardo Luca Vigan\u00f2",
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  "author": "Edoardo Luca Vigan\u00f2",
            
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  "author_email": "edoardo.vigano@marionegri.it",
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  "author_email": "edoardo.vigano@marionegri.it",
            
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  "category": [],
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  "category": [],
            
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  "cells_number": "",
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  "cells_number": "",
            
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  "content": [],
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  "content": [],
            
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
            
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  "culture_medium": [],
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  "culture_medium": [],
            
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  "dimension": [],
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  "dimension": [],
            
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  "experiment_date": "",
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  "experiment_date": "",
            
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  "groups": [],
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  "groups": [],
            
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  "id": "9c0d9822-0d03-4da6-b073-df74b253cec5",
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  "id": "9c0d9822-0d03-4da6-b073-df74b253cec5",
            
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  "isopen": false,
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  "isopen": false,
            
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  "license_id": "notspecified",
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  "license_id": "notspecified",
            
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  "license_title": "License not specified",
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  "license_title": "License not specified",
            
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  "maintainer": "",
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  "maintainer": "",
            
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  "maintainer_email": "",
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  "maintainer_email": "",
            
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  "metadata_created": "2024-10-25T12:59:16.286721",
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  "metadata_created": "2024-10-25T12:59:16.286721",
            
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  "metadata_modified": "2024-10-25T12:59:16.286728",
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  "metadata_modified": "2024-10-25T13:00:41.070218",
            
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  "model": [],
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  "model": [],
            
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  "name": "increased-myocardial-oxidative-stress",
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  "name": "increased-myocardial-oxidative-stress",
            
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  "notes": "[Mitochondrial complexes inhibition leading to left 
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  "notes": "[Mitochondrial complexes inhibition leading to left 
            
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ventricular function decrease via increased myocardial oxidative 
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ventricular function decrease via increased myocardial oxidative 
            
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stress]\r\n\r\nIn accordance with the events outlined in the linear 
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stress]\r\n\r\nIn accordance with the events outlined in the linear 
            
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AOP framework for cardiotoxicity developed in ALTERNATIVE project we 
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AOP framework for cardiotoxicity developed in ALTERNATIVE project we 
            
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collected data from biological assays providing information on the 
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collected data from biological assays providing information on the 
            
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potential toxic interactions between chemicals and specific biological 
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potential toxic interactions between chemicals and specific biological 
            
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targets. \r\n\r\nList of assays considered for evaluating chemicals 
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targets. \r\n\r\nList of assays considered for evaluating chemicals 
            
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regarding Mitochondrial complexes inhibition leading to left 
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regarding Mitochondrial complexes inhibition leading to left 
            
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ventricular function decrease via increased myocardial oxidative 
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ventricular function decrease via increased myocardial oxidative 
            
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stress:\r\nAPR HepG2 P-H2AX 24 h dn,  APR HepG2 P-H2AX 24 h up,  APR 
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stress:\r\nAPR HepG2 P-H2AX 24 h dn,  APR HepG2 P-H2AX 24 h up,  APR 
            
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HepG2 P-H2AX 72 h dn,  APR HepG2 P-H2AX 72 h up,  APR HepG2 
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HepG2 P-H2AX 72 h dn,  APR HepG2 P-H2AX 72 h up,  APR HepG2 
            
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StressKinase 24 h dn,  APR HepG2 StressKinase 24 h up,  APR HepG2 
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StressKinase 24 h dn,  APR HepG2 StressKinase 24 h up,  APR HepG2 
            
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StressKinase 72 h dn\r\n\r\nAOP source: 
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StressKinase 72 h dn\r\n\r\nAOP source: 
            
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https://aopwiki.org/aops/479\r\npaper: 
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https://aopwiki.org/aops/479\r\npaper: 
            
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https://doi.org/10.3390/toxics12010087",
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https://doi.org/10.3390/toxics12010087",
            
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  "num_resources": 0,
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  "num_tags": 2,
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  "num_tags": 2,
            
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  "organization": {
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  "organization": {
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2023-03-17T17:42:44.917090",
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    "created": "2023-03-17T17:42:44.917090",
            
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    "description": "The Mario Negri Institute for Pharmacological 
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    "description": "The Mario Negri Institute for Pharmacological 
            
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Research (www.marionegri.it) is a not-for-profit 
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Research (www.marionegri.it) is a not-for-profit 
            
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
            
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1961 and later (1984) opened research units in Bergamo, currently 
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1961 and later (1984) opened research units in Bergamo, currently 
            
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located at the\r\nKilometro Rosso Science and Technology Park, and 
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located at the\r\nKilometro Rosso Science and Technology Park, and 
            
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Ranica (near Bergamo)",
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Ranica (near Bergamo)",
            
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "irfmn",
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    "name": "irfmn",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "IRFMN",
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    "title": "IRFMN",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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  "private": false,
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  "private": false,
            
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  "ratio_hipsccms_hcaecs": "",
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  "ratio_hipsccms_hcaecs": "",
            
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  "relationships_as_object": [],
            
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  "relationships_as_subject": [],
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  "relationships_as_subject": [],
            
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  "replicates_number": "",
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  "replicates_number": "",
            
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  "resources": [],
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      "created": "2024-10-25T13:00:41.137083",
            
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      "datastore_active": false,
            
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      "description": "QSAR-ready dataset for Mitochondrial complexes 
            
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inhibition leading to left ventricular function decrease via increased 
            
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myocardial oxidative stress\r\n\r\nlabels: Binary endpoint",
            
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      "format": "CSV",
            
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      "hash": "",
            
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      "id": "94dd3d13-992a-49c2-9fc4-37fde88b781d",
            
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      "last_modified": "2024-10-25T13:00:41.046658",
            
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      "mimetype": null,
            
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      "mimetype_inner": null,
            
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      "name": "OxidativeStress_dataset_CDDD.csv",
            
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      "package_id": "9c0d9822-0d03-4da6-b073-df74b253cec5",
            
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      "size": 3702777,
            
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      "state": "active",
            
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      "url": 
            
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92a-49c2-9fc4-37fde88b781d/download/oxidativestress_dataset_cddd.csv",
            
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      "url_type": "upload"
            
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  ],
            
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  "size": 0,
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  "size": 3702777,
            
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  "state": "draft",
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  "state": "draft",
            
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  "tags": [
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  "tags": [
            
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    {
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    {
            
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      "display_name": "IncreaseOxidativeStress",
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      "display_name": "IncreaseOxidativeStress",
            
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      "id": "5f87cf59-de95-445d-897e-8d8146d0aac6",
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      "id": "5f87cf59-de95-445d-897e-8d8146d0aac6",
            
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      "name": "IncreaseOxidativeStress",
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      "name": "IncreaseOxidativeStress",
            
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      "state": "active",
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      "state": "active",
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "cardiotoxicity",
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      "display_name": "cardiotoxicity",
            
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
            
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      "name": "cardiotoxicity",
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      "name": "cardiotoxicity",
            
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      "vocabulary_id": null
            
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    }
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    }
            
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  ],
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  ],
            
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  "title": "Increased myocardial oxidative stress",
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  "title": "Increased myocardial oxidative stress",
            
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  "toxin": [],
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  "toxin": [],
            
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  "type": "dataset",
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  "type": "dataset",
            
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  "url": "",
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  "url": "",
            
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  "version": "0.2"
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  "version": "0.2"
            
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}
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}