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{
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{
            
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  "age_type": [],
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  "age_type": [],
            
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  "author": "Edoardo Luca Vigan\u00f2",
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  "author": "Edoardo Luca Vigan\u00f2",
            
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  "author_email": "edoardo.vigano@marionegri.it",
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  "author_email": "edoardo.vigano@marionegri.it",
            
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  "category": [],
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  "category": [],
            
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  "cells_number": "",
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  "cells_number": "",
            
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  "content": [],
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  "content": [],
            
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
            
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  "culture_medium": [],
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  "culture_medium": [],
            
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  "dimension": [],
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  "dimension": [],
            
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  "experiment_date": "",
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  "experiment_date": "",
            
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  "groups": [],
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  "groups": [],
            
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  "id": "5b2169a3-5146-4cbb-913b-9ad60de0907e",
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  "id": "5b2169a3-5146-4cbb-913b-9ad60de0907e",
            
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  "isopen": false,
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  "isopen": false,
            
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  "license_id": "",
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  "license_id": "",
            
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  "license_title": "",
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  "license_title": "",
            
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  "maintainer": "",
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  "maintainer": "",
            
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  "maintainer_email": "",
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  "maintainer_email": "",
            
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  "metadata_created": "2024-10-25T13:46:36.635765",
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  "metadata_created": "2024-10-25T13:46:36.635765",
            
n
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  "metadata_modified": "2024-10-25T13:47:39.536218",
n
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  "metadata_modified": "2024-10-25T14:20:59.262419",
            
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  "model": [],
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  "model": [],
            
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  "name": 
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  "name": 
            
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xes-inhibition-leading-to-heart-failure-via-decreased-atp-production",
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xes-inhibition-leading-to-heart-failure-via-decreased-atp-production",
            
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  "notes": "[Mitochondrial complexes inhibition leading to heart 
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  "notes": "[Mitochondrial complexes inhibition leading to heart 
            
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failure via decreased ATP production]\r\n\r\nIn accordance with the 
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failure via decreased ATP production]\r\n\r\nIn accordance with the 
            
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events outlined in the linear AOP framework for cardiotoxicity 
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events outlined in the linear AOP framework for cardiotoxicity 
            
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developed in the ALTERNATIVE project, we collected data from 
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developed in the ALTERNATIVE project, we collected data from 
            
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biological assays providing information on the potential toxic 
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biological assays providing information on the potential toxic 
            
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interactions between chemicals and specific biological 
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interactions between chemicals and specific biological 
            
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targets.\r\n\r\nBinary Endpoint: Mitochondrial complexes 
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targets.\r\n\r\nList of assays considered to evaluate chemicals 
            
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inhibition\r\n\r\nAOP source: https://aopwiki.org/aops/480\r\nPaper: 
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activity for Mitochondrial complexes inhibition:\r\nCCTE Simmons MITO 
            
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basal resp rate OCR dn,  CCTE Simmons MITO basal resp rate OCR up,  
            
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CCTE Simmons MITO inhib resp rate OCR dn,  CCTE Simmons MITO inhib 
            
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resp rate OCR up,  CCTE Simmons MITO max resp rate OCR dn,  CCTE 
            
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Simmons MITO max resp rate OCR up\r\n\r\n\r\nBinary Endpoint: 
            
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Mitochondrial complexes inhibition\r\n\r\nAOP source: 
            
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https://aopwiki.org/aops/480\r\nPaper: 
            
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https://doi.org/10.3390/toxics12010087\r\n\r\n\r\n",
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https://doi.org/10.3390/toxics12010087\r\n\r\n\r\n",
            
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  "num_resources": 1,
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  "num_resources": 1,
            
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  "num_tags": 2,
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  "num_tags": 2,
            
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  "organization": {
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  "organization": {
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2023-03-17T17:42:44.917090",
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    "created": "2023-03-17T17:42:44.917090",
            
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    "description": "The Mario Negri Institute for Pharmacological 
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    "description": "The Mario Negri Institute for Pharmacological 
            
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Research (www.marionegri.it) is a not-for-profit 
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Research (www.marionegri.it) is a not-for-profit 
            
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
            
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1961 and later (1984) opened research units in Bergamo, currently 
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1961 and later (1984) opened research units in Bergamo, currently 
            
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located at the\r\nKilometro Rosso Science and Technology Park, and 
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located at the\r\nKilometro Rosso Science and Technology Park, and 
            
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Ranica (near Bergamo)",
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Ranica (near Bergamo)",
            
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "irfmn",
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    "name": "irfmn",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "IRFMN",
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    "title": "IRFMN",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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  "private": false,
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  "private": false,
            
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  "ratio_hipsccms_hcaecs": "",
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  "ratio_hipsccms_hcaecs": "",
            
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  "relationships_as_object": [],
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  "relationships_as_object": [],
            
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  "relationships_as_subject": [],
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  "relationships_as_subject": [],
            
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  "replicates_number": "",
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  "replicates_number": "",
            
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  "resources": [
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  "resources": [
            
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    {
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    {
            
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      "cache_last_updated": null,
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      "cache_last_updated": null,
            
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      "cache_url": null,
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      "cache_url": null,
            
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      "created": "2024-10-25T13:47:37.782360",
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      "created": "2024-10-25T13:47:37.782360",
            
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      "datastore_active": false,
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      "datastore_active": true,
            
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      "description": "QSAR-ready database for Mitochondrial complexes 
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      "description": "QSAR-ready database for Mitochondrial complexes 
            
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inhibition\r\n\r\nBinary Endpoint {0:inactive, 1:active}",
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inhibition\r\n\r\nBinary Endpoint {0:inactive, 1:active}",
            
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      "format": "CSV",
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      "format": "CSV",
            
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      "hash": "",
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      "hash": "",
            
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      "id": "42b0cf31-9aa2-465a-8264-8cd31f5741bf",
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      "id": "42b0cf31-9aa2-465a-8264-8cd31f5741bf",
            
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      "last_modified": "2024-10-25T13:47:37.746232",
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      "last_modified": "2024-10-25T13:47:37.746232",
            
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      "metadata_modified": "2024-10-25T13:47:39.541372",
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      "mimetype": null,
            
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      "mimetype_inner": null,
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      "mimetype_inner": null,
            
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      "name": "Inhibition_mitochondrial_complexes_dataset_CDDD.csv",
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      "name": "Inhibition_mitochondrial_complexes_dataset_CDDD.csv",
            
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      "package_id": "5b2169a3-5146-4cbb-913b-9ad60de0907e",
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      "package_id": "5b2169a3-5146-4cbb-913b-9ad60de0907e",
            
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      "position": 0,
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      "size": 1343270,
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      "size": 1343270,
            
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      "state": "active",
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      "state": "active",
            
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      "url": 
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      "url": 
            
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f5741bf/download/inhibition_mitochondrial_complexes_dataset_cddd.csv",
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f5741bf/download/inhibition_mitochondrial_complexes_dataset_cddd.csv",
            
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      "url_type": "upload"
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      "url_type": "upload"
            
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    }
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    }
            
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  ],
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  ],
            
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  "size": 1343270,
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  "size": 1343270,
            
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  "state": "active",
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  "state": "active",
            
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  "tags": [
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  "tags": [
            
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    {
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    {
            
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      "display_name": "Mitochondrial complexes inhibition",
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      "display_name": "Mitochondrial complexes inhibition",
            
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      "id": "f21e9118-1844-4b7d-aa96-e4fa3d9542b7",
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      "id": "f21e9118-1844-4b7d-aa96-e4fa3d9542b7",
            
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      "name": "Mitochondrial complexes inhibition",
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      "name": "Mitochondrial complexes inhibition",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "cardiotoxicity",
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      "display_name": "cardiotoxicity",
            
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
            
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      "name": "cardiotoxicity",
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      "name": "cardiotoxicity",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    }
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    }
            
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  ],
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  ],
            
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  "title": "Mitochondrial complexes inhibition leading to heart 
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  "title": "Mitochondrial complexes inhibition leading to heart 
            
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failure via decreased ATP production",
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failure via decreased ATP production",
            
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  "toxin": [],
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  "toxin": [],
            
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  "type": "dataset",
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  "type": "dataset",
            
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  "url": "",
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  "url": "",
            
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  "version": "0.2"
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  "version": "0.2"
            
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}
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}