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{
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{
            
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  "age_type": [],
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  "age_type": [],
            
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  "author": "Edoardo Luca Vigan\u00f2",
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  "author": "Edoardo Luca Vigan\u00f2",
            
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  "author_email": "edoardo.vigano@marionegri.it",
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  "author_email": "edoardo.vigano@marionegri.it",
            
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  "category": [],
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  "category": [],
            
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  "cells_number": "",
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  "cells_number": "",
            
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  "content": [],
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  "content": [],
            
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
            
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  "culture_medium": [],
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  "culture_medium": [],
            
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  "dimension": [],
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  "dimension": [],
            
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  "experiment_date": "",
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  "experiment_date": "",
            
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  "groups": [],
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  "groups": [],
            
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  "id": "40fa2e07-8a2d-46d9-b0ec-3600f7bf391d",
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  "id": "40fa2e07-8a2d-46d9-b0ec-3600f7bf391d",
            
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  "isopen": false,
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  "isopen": false,
            
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  "license_id": "notspecified",
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  "license_id": "notspecified",
            
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  "license_title": "License not specified",
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  "license_title": "License not specified",
            
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  "maintainer": "",
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  "maintainer": "",
            
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  "maintainer_email": "",
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  "maintainer_email": "",
            
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  "metadata_created": "2024-10-25T14:15:45.385922",
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  "metadata_created": "2024-10-25T14:15:45.385922",
            
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  "metadata_modified": "2024-10-25T14:15:45.385928",
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  "metadata_modified": "2024-10-25T14:17:20.371459",
            
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  "model": [],
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  "model": [],
            
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  "name": "herg-inhibition-leading-to-cardiac-toxicity",
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  "name": "herg-inhibition-leading-to-cardiac-toxicity",
            
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  "notes": "hERG channel blockade leading to sudden cardiac 
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  "notes": "hERG channel blockade leading to sudden cardiac 
            
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death\r\n\r\nIncreased mortality triggered by drug-mediated blockade 
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death\r\n\r\nIncreased mortality triggered by drug-mediated blockade 
            
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of human ether-a-gogo-related gene (hERG) channel. The inhibition of 
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of human ether-a-gogo-related gene (hERG) channel. The inhibition of 
            
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rapid delayed rectifying potassium current, prolongation of action 
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rapid delayed rectifying potassium current, prolongation of action 
            
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potential duration, prolongation of QT interval, and Torsades de 
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potential duration, prolongation of QT interval, and Torsades de 
            
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Pointes. Overall, all these steps indicate that there has been a 
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Pointes. Overall, all these steps indicate that there has been a 
            
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disruption in cardiac electrophysiology, leading to sudden cardiac 
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disruption in cardiac electrophysiology, leading to sudden cardiac 
            
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death on an individual level.\r\n\r\nData: ID (ChEMBL240) assigned to 
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death on an individual level.\r\n\r\nData: ID (ChEMBL240) assigned to 
            
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the hERG channel. To ensure data validity, the database was mined 
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the hERG channel. To ensure data validity, the database was mined 
            
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retaining only those entries matching the following criteria already 
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retaining only those entries matching the following criteria already 
            
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suggested in the literature: \r\n1) annotated exclusively with IC50 
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suggested in the literature: \r\n1) annotated exclusively with IC50 
            
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(11,144 entries) measures, \r\n2) referring to assays conducted on 
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(11,144 entries) measures, \r\n2) referring to assays conducted on 
            
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human targets (\u201ctarget_organism\u201d = \u201cHomo 
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human targets (\u201ctarget_organism\u201d = \u201cHomo 
            
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sapiens\u201d), \r\n3) marked as direct binding 
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sapiens\u201d), \r\n3) marked as direct binding 
            
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(\u201cassay_type\u201d = \u201cB\u201d), and 4) free of warnings in 
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(\u201cassay_type\u201d = \u201cB\u201d), and 4) free of warnings in 
            
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the \u201cdata_validity_comment\u201d field\r\n\r\nAOP source: 
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the \u201cdata_validity_comment\u201d field\r\n\r\nAOP source: 
            
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https://aopwiki.org/aops/433\r\nData source: 
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https://aopwiki.org/aops/433\r\nData source: 
            
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https://www.ebi.ac.uk/chembl/\r\nData curation: 
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https://www.ebi.ac.uk/chembl/\r\nData curation: 
            
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10.3389/fphar.2022.951083",
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10.3389/fphar.2022.951083",
            
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  "num_resources": 0,
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  "num_resources": 1,
            
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  "num_tags": 2,
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  "num_tags": 2,
            
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  "organization": {
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  "organization": {
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2023-03-17T17:42:44.917090",
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    "created": "2023-03-17T17:42:44.917090",
            
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    "description": "The Mario Negri Institute for Pharmacological 
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    "description": "The Mario Negri Institute for Pharmacological 
            
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Research (www.marionegri.it) is a not-for-profit 
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Research (www.marionegri.it) is a not-for-profit 
            
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
            
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1961 and later (1984) opened research units in Bergamo, currently 
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1961 and later (1984) opened research units in Bergamo, currently 
            
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located at the\r\nKilometro Rosso Science and Technology Park, and 
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located at the\r\nKilometro Rosso Science and Technology Park, and 
            
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Ranica (near Bergamo)",
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Ranica (near Bergamo)",
            
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "irfmn",
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    "name": "irfmn",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "IRFMN",
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    "title": "IRFMN",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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  "private": false,
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  "private": false,
            
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  "ratio_hipsccms_hcaecs": "",
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  "ratio_hipsccms_hcaecs": "",
            
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  "relationships_as_object": [],
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  "relationships_as_object": [],
            
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  "relationships_as_subject": [],
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  "relationships_as_subject": [],
            
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  "replicates_number": "",
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  "replicates_number": "",
            
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  "resources": [],
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  "resources": [
            
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  "size": 0,
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    {
            
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      "cache_last_updated": null,
            
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      "cache_url": null,
            
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      "created": "2024-10-25T14:17:20.387801",
            
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      "datastore_active": false,
            
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      "description": "QSAR-ready dataset for hERG channel 
            
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blockade.\r\nBinary Endpoint: {0:inactive, 1:active}",
            
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      "format": "CSV",
            
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      "hash": "",
            
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      "id": "ed9f61eb-505f-4e80-a2e2-1b4d173f7e90",
            
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      "last_modified": "2024-10-25T14:17:20.347492",
            
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      "metadata_modified": "2024-10-25T14:17:20.376367",
            
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      "mimetype": null,
            
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      "mimetype_inner": null,
            
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      "name": "hERG_channels_inhibitors_dataset_CDDD.csv",
            
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      "package_id": "40fa2e07-8a2d-46d9-b0ec-3600f7bf391d",
            
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      "position": 0,
            
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      "resource_type": null,
            
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      "size": 48929458,
            
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      "state": "active",
            
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      "url": 
            
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a2e2-1b4d173f7e90/download/herg_channels_inhibitors_dataset_cddd.csv",
            
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      "url_type": "upload"
            
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    }
            
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  ],
            
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  "size": 48929458,
            
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  "state": "draft",
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  "state": "draft",
            
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  "tags": [
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  "tags": [
            
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    {
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    {
            
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      "display_name": "cardiotoxicity",
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      "display_name": "cardiotoxicity",
            
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
            
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      "name": "cardiotoxicity",
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      "name": "cardiotoxicity",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "hERG",
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      "display_name": "hERG",
            
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      "id": "27051182-ce02-4ef0-9adb-5813db2acecc",
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      "id": "27051182-ce02-4ef0-9adb-5813db2acecc",
            
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      "name": "hERG",
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      "name": "hERG",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    }
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    }
            
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  ],
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  ],
            
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  "title": "hERG inhibition leading to cardiac toxicity",
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  "title": "hERG inhibition leading to cardiac toxicity",
            
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  "toxin": [],
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  "toxin": [],
            
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  "type": "dataset",
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  "type": "dataset",
            
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  "url": "",
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  "url": "",
            
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  "version": "0.1"
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  "version": "0.1"
            
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}
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}