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{
f
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{
            
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  "age_type": [],
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  "age_type": [],
            
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  "author": "Edoardo Luca Vigan\u00f2",
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  "author": "Edoardo Luca Vigan\u00f2",
            
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  "author_email": "edoardo.vigano@marionegri.it",
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  "author_email": "edoardo.vigano@marionegri.it",
            
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  "category": [],
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  "category": [],
            
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  "cells_number": "",
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  "cells_number": "",
            
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  "content": [],
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  "content": [],
            
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
            
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  "culture_medium": [],
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  "culture_medium": [],
            
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  "dimension": [],
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  "dimension": [],
            
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  "experiment_date": "",
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  "experiment_date": "",
            
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  "groups": [],
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  "groups": [],
            
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  "id": "a0a50f84-816f-4499-8f86-7b02a1e303f7",
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  "id": "a0a50f84-816f-4499-8f86-7b02a1e303f7",
            
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  "isopen": false,
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  "isopen": false,
            
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  "license_id": "notspecified",
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  "license_id": "notspecified",
            
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  "license_title": "License not specified",
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  "license_title": "License not specified",
            
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  "maintainer": "",
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  "maintainer": "",
            
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  "maintainer_email": "",
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  "maintainer_email": "",
            
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  "metadata_created": "2024-10-25T14:24:45.042837",
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  "metadata_created": "2024-10-25T14:24:45.042837",
            
n
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  "metadata_modified": "2024-10-25T14:25:42.643152",
n
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  "metadata_modified": "2024-10-25T14:25:43.589947",
            
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  "model": [],
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  "model": [],
            
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  "name": "aryl-hydrocarbon-receptor-activation",
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  "name": "aryl-hydrocarbon-receptor-activation",
            
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  "notes": "Aryl Hydrocarbon Receptor Activation\r\n\r\nData:\r\nThe 
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  "notes": "Aryl Hydrocarbon Receptor Activation\r\n\r\nData:\r\nThe 
            
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Target ID (CHEMBL3201) is assigned to Aryl Hydrocarbon Receptor (AHR) 
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Target ID (CHEMBL3201) is assigned to Aryl Hydrocarbon Receptor (AHR) 
            
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activation, so we collected all data related to this endpoint. To 
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activation, so we collected all data related to this endpoint. To 
            
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define a binary classification suitable for our purposes, we 
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define a binary classification suitable for our purposes, we 
            
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considered the category comments provided in the database and pChEMBL, 
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considered the category comments provided in the database and pChEMBL, 
            
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a standardized logarithmic transformation of activity values (e.g., 
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a standardized logarithmic transformation of activity values (e.g., 
            
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IC50, EC50, Ki, Kd, etc.), which facilitates the comparison of 
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IC50, EC50, Ki, Kd, etc.), which facilitates the comparison of 
            
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different types of bioactivity data. Data marked as inconclusive or 
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different types of bioactivity data. Data marked as inconclusive or 
            
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with a validity comment of 'not outside typical range' were discarded. 
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with a validity comment of 'not outside typical range' were discarded. 
            
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Initially, we downloaded 1,071 entries, and after data curation, 347 
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Initially, we downloaded 1,071 entries, and after data curation, 347 
            
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chemicals were retained in our database. For compounds without a 
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chemicals were retained in our database. For compounds without a 
            
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predefined category, we classified chemicals with a pChEMBL > 0.5 as 
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predefined category, we classified chemicals with a pChEMBL > 0.5 as 
            
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active.\r\n\r\nEndpoint:\r\nBinary endpoint: {0:inactive, 1:active}",
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active.\r\n\r\nEndpoint:\r\nBinary endpoint: {0:inactive, 1:active}",
            
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  "num_resources": 1,
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  "num_resources": 1,
            
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  "num_tags": 2,
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  "num_tags": 2,
            
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  "organization": {
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  "organization": {
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2023-03-17T17:42:44.917090",
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    "created": "2023-03-17T17:42:44.917090",
            
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    "description": "The Mario Negri Institute for Pharmacological 
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    "description": "The Mario Negri Institute for Pharmacological 
            
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Research (www.marionegri.it) is a not-for-profit 
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Research (www.marionegri.it) is a not-for-profit 
            
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
            
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1961 and later (1984) opened research units in Bergamo, currently 
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1961 and later (1984) opened research units in Bergamo, currently 
            
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located at the\r\nKilometro Rosso Science and Technology Park, and 
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located at the\r\nKilometro Rosso Science and Technology Park, and 
            
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Ranica (near Bergamo)",
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Ranica (near Bergamo)",
            
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "irfmn",
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    "name": "irfmn",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "IRFMN",
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    "title": "IRFMN",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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  "private": false,
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  "private": false,
            
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  "ratio_hipsccms_hcaecs": "",
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  "ratio_hipsccms_hcaecs": "",
            
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  "relationships_as_object": [],
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  "relationships_as_object": [],
            
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  "relationships_as_subject": [],
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  "relationships_as_subject": [],
            
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  "replicates_number": "",
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  "replicates_number": "",
            
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  "resources": [
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  "resources": [
            
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    {
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    {
            
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      "cache_last_updated": null,
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      "cache_last_updated": null,
            
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      "cache_url": null,
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      "cache_url": null,
            
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      "created": "2024-10-25T14:25:42.670662",
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      "created": "2024-10-25T14:25:42.670662",
            
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      "datastore_active": false,
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      "datastore_active": false,
            
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      "description": "QSAR-ready database for Aryl Hydrocarbon 
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      "description": "QSAR-ready database for Aryl Hydrocarbon 
            
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Receptor (AHR) Activation\r\n\r\nBinary Endpoint: {0:inactive, 
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Receptor (AHR) Activation\r\n\r\nBinary Endpoint: {0:inactive, 
            
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1:active}",
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1:active}",
            
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      "format": "CSV",
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      "format": "CSV",
            
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      "hash": "",
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      "hash": "",
            
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      "id": "749952d6-c79c-4e59-8907-aaed39a6ee99",
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      "id": "749952d6-c79c-4e59-8907-aaed39a6ee99",
            
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      "last_modified": null,
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      "last_modified": null,
            
n
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      "metadata_modified": "2024-10-25T14:25:42.655238",
n
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      "metadata_modified": "2024-10-25T14:25:43.635537",
            
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      "mimetype": null,
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      "mimetype": null,
            
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      "mimetype_inner": null,
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      "mimetype_inner": null,
            
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      "name": "Aryl Hydrocarbon Receptor (AHR) ",
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      "name": "Aryl Hydrocarbon Receptor (AHR) ",
            
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      "package_id": "a0a50f84-816f-4499-8f86-7b02a1e303f7",
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      "package_id": "a0a50f84-816f-4499-8f86-7b02a1e303f7",
            
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      "position": 0,
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      "position": 0,
            
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      "resource_type": null,
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      "resource_type": null,
            
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      "size": null,
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      "size": null,
            
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      "state": "active",
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      "state": "active",
            
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      "url": "",
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      "url": "",
            
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      "url_type": null
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      "url_type": null
            
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    }
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    }
            
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  ],
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  ],
            
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  "size": 0,
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  "size": 0,
            
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  "state": "draft",
t
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  "state": "active",
            
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  "tags": [
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  "tags": [
            
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    {
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    {
            
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      "display_name": "Aryl Hydrocarbon Receptor",
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      "display_name": "Aryl Hydrocarbon Receptor",
            
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      "id": "7c962933-1735-4acf-bdc1-b88e9cd5d36e",
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      "id": "7c962933-1735-4acf-bdc1-b88e9cd5d36e",
            
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      "name": "Aryl Hydrocarbon Receptor",
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      "name": "Aryl Hydrocarbon Receptor",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "cardiotox",
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      "display_name": "cardiotox",
            
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      "id": "576d16b5-5a7d-479e-b678-c26874f5e3f6",
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      "id": "576d16b5-5a7d-479e-b678-c26874f5e3f6",
            
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      "name": "cardiotox",
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      "name": "cardiotox",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    }
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    }
            
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  ],
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  ],
            
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  "title": "Aryl Hydrocarbon Receptor Activation",
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  "title": "Aryl Hydrocarbon Receptor Activation",
            
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  "toxin": [],
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  "toxin": [],
            
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  "type": "dataset",
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  "type": "dataset",
            
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  "url": "",
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  "url": "",
            
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  "version": "0.1"
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  "version": "0.1"
            
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}
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}