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{
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{
            
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  "age_type": [],
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  "age_type": [],
            
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  "author": "Edoardo Luca Vigan\u00f2",
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  "author": "Edoardo Luca Vigan\u00f2",
            
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  "author_email": "edoardo.vigano@marionegri.it",
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  "author_email": "edoardo.vigano@marionegri.it",
            
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  "category": [],
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  "category": [],
            
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  "cells_number": "",
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  "cells_number": "",
            
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  "content": [],
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  "content": [],
            
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
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  "creator_user_id": "56153fff-4293-4f39-9723-fcc904de812a",
            
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  "culture_medium": [],
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  "culture_medium": [],
            
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  "dimension": [],
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  "dimension": [],
            
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  "experiment_date": "",
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  "experiment_date": "",
            
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  "groups": [],
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  "groups": [],
            
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  "id": "011fac9e-86c9-44d5-b5f9-96cfaa15ce06",
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  "id": "011fac9e-86c9-44d5-b5f9-96cfaa15ce06",
            
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  "isopen": false,
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  "isopen": false,
            
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  "license_id": "",
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  "license_id": "",
            
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  "license_title": "",
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  "license_title": "",
            
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  "maintainer": "",
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  "maintainer": "",
            
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  "maintainer_email": "",
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  "maintainer_email": "",
            
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  "metadata_created": "2024-10-25T12:21:33.884724",
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  "metadata_created": "2024-10-25T12:21:33.884724",
            
n
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  "metadata_modified": "2024-10-25T12:23:13.969762",
n
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  "metadata_modified": "2024-10-25T12:23:21.996202",
            
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  "model": [],
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  "model": [],
            
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  "name": "increase-mitochondrial-dysfunction-cddd2",
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  "name": "increase-mitochondrial-dysfunction-cddd2",
            
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  "notes": "Increase Mitochondrial Dysfunction\r\n\r\nIn accordance 
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  "notes": "Increase Mitochondrial Dysfunction\r\n\r\nIn accordance 
            
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with the events outlined in the linear AOP framework for 
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with the events outlined in the linear AOP framework for 
            
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cardiotoxicity developed in the ALTERNATIVE project, we collected data 
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cardiotoxicity developed in the ALTERNATIVE project, we collected data 
            
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from biological assays providing information on the potential toxic 
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from biological assays providing information on the potential toxic 
            
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interactions between chemicals and specific biological targets. In 
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interactions between chemicals and specific biological targets. In 
            
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this case the endpoint under consideration in the Mitochondrial 
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this case the endpoint under consideration in the Mitochondrial 
            
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Dysfunction.\r\n\r\nBinary Endpoint.\r\n\r\nList of the assays 
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Dysfunction.\r\n\r\nBinary Endpoint.\r\n\r\nList of the assays 
            
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considered for evaluate mitochondrial dysfunction activity:\r\nAPR 
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considered for evaluate mitochondrial dysfunction activity:\r\nAPR 
            
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HepG2 MitoMass 24 h dn, APR HepG2 MitoMass 24 h up, APR HepG2 MitoMass 
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HepG2 MitoMass 24 h dn, APR HepG2 MitoMass 24 h up, APR HepG2 MitoMass 
            
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72 h dn, APR HepG2 MitoMass 72 h up, APR HepG2 MitoMembPot 24 h dn, 
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72 h dn, APR HepG2 MitoMass 72 h up, APR HepG2 MitoMembPot 24 h dn, 
            
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APR HepG2 MitoMembPot 24 h up, APR HepG2 MitoMembPot 72 h dn, APR 
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APR HepG2 MitoMembPot 24 h up, APR HepG2 MitoMembPot 72 h dn, APR 
            
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HepG2 MitoMembPot 72 h up, ATG XTT Cytotoxicity up, TOX21 MMP ratio 
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HepG2 MitoMembPot 72 h up, ATG XTT Cytotoxicity up, TOX21 MMP ratio 
            
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down, TOX21 MMP ratio up, TOX21 MMP rhodamine\r\n\r\nAOP source: 
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down, TOX21 MMP ratio up, TOX21 MMP rhodamine\r\n\r\nAOP source: 
            
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https://aopwiki.org/events/177\r\n\r\nData curation and data source: 
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https://aopwiki.org/events/177\r\n\r\nData curation and data source: 
            
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https://doi.org/10.3390/toxics12010087 ",
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https://doi.org/10.3390/toxics12010087 ",
            
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  "num_resources": 1,
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  "num_resources": 1,
            
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  "num_tags": 2,
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  "num_tags": 2,
            
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  "organization": {
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  "organization": {
            
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    "approval_status": "approved",
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    "approval_status": "approved",
            
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    "created": "2023-03-17T17:42:44.917090",
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    "created": "2023-03-17T17:42:44.917090",
            
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    "description": "The Mario Negri Institute for Pharmacological 
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    "description": "The Mario Negri Institute for Pharmacological 
            
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Research (www.marionegri.it) is a not-for-profit 
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Research (www.marionegri.it) is a not-for-profit 
            
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
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biomedical\r\nresearch organization.\r\nIt was established in Milan in 
            
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1961 and later (1984) opened research units in Bergamo, currently 
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1961 and later (1984) opened research units in Bergamo, currently 
            
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located at the\r\nKilometro Rosso Science and Technology Park, and 
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located at the\r\nKilometro Rosso Science and Technology Park, and 
            
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Ranica (near Bergamo)",
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Ranica (near Bergamo)",
            
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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    "id": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
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    "image_url": "2023-03-17-174244.890524IMNOrizzontaleRGB.png",
            
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    "is_organization": true,
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    "is_organization": true,
            
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    "name": "irfmn",
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    "name": "irfmn",
            
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    "state": "active",
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    "state": "active",
            
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    "title": "IRFMN",
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    "title": "IRFMN",
            
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    "type": "organization"
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    "type": "organization"
            
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  },
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  },
            
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
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  "owner_org": "e50db934-20d8-4a27-80a2-ce67bc4d99db",
            
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  "private": false,
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  "private": false,
            
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  "ratio_hipsccms_hcaecs": "",
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  "ratio_hipsccms_hcaecs": "",
            
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  "relationships_as_object": [],
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  "relationships_as_object": [],
            
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  "relationships_as_subject": [],
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  "relationships_as_subject": [],
            
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  "replicates_number": "",
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  "replicates_number": "",
            
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  "resources": [
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  "resources": [
            
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    {
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    {
            
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      "cache_last_updated": null,
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      "cache_last_updated": null,
            
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      "cache_url": null,
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      "cache_url": null,
            
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      "created": "2024-10-25T12:23:14.036860",
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      "created": "2024-10-25T12:23:14.036860",
            
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      "datastore_active": false,
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      "datastore_active": false,
            
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      "description": "QSAR ready database for Mitochondrial 
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      "description": "QSAR ready database for Mitochondrial 
            
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Dysfunction toxicity.\r\n\r\nlabels: binary endpoint {0: inactive, 1: 
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Dysfunction toxicity.\r\n\r\nlabels: binary endpoint {0: inactive, 1: 
            
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active}",
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active}",
            
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      "format": "CSV",
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      "format": "CSV",
            
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      "hash": "",
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      "hash": "",
            
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      "id": "6d822a80-fcef-4625-8e78-4873528f6f0a",
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      "id": "6d822a80-fcef-4625-8e78-4873528f6f0a",
            
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      "last_modified": "2024-10-25T12:23:13.946675",
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      "last_modified": "2024-10-25T12:23:13.946675",
            
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      "metadata_modified": "2024-10-25T12:23:13.978248",
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      "metadata_modified": "2024-10-25T12:23:22.035423",
            
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      "mimetype": null,
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      "mimetype": null,
            
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      "mimetype_inner": null,
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      "mimetype_inner": null,
            
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      "name": "Increase_mitochondrial_dysfunction_dataset_CDDD.csv",
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      "name": "Increase_mitochondrial_dysfunction_dataset_CDDD.csv",
            
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      "package_id": "011fac9e-86c9-44d5-b5f9-96cfaa15ce06",
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      "package_id": "011fac9e-86c9-44d5-b5f9-96cfaa15ce06",
            
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      "position": 0,
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      "position": 0,
            
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      "resource_type": null,
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      "resource_type": null,
            
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      "size": 28932502,
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      "size": 28932502,
            
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      "state": "active",
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      "state": "active",
            
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      "url": 
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      "url": 
            
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28f6f0a/download/increase_mitochondrial_dysfunction_dataset_cddd.csv",
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28f6f0a/download/increase_mitochondrial_dysfunction_dataset_cddd.csv",
            
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      "url_type": "upload"
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      "url_type": "upload"
            
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    }
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    }
            
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  ],
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  ],
            
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  "size": 28932502,
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  "size": 28932502,
            
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  "state": "draft",
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  "state": "active",
            
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  "tags": [
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  "tags": [
            
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    {
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    {
            
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      "display_name": "Mitochondrial dysfunction",
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      "display_name": "Mitochondrial dysfunction",
            
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      "id": "b6ac39d6-dd68-4012-81ad-3dbf4f6a90b3",
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      "id": "b6ac39d6-dd68-4012-81ad-3dbf4f6a90b3",
            
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      "name": "Mitochondrial dysfunction",
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      "name": "Mitochondrial dysfunction",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    },
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    },
            
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    {
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    {
            
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      "display_name": "cardiotoxicity",
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      "display_name": "cardiotoxicity",
            
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
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      "id": "8ba178e0-bd1e-46ad-aa0b-a1e1c430545b",
            
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      "name": "cardiotoxicity",
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      "name": "cardiotoxicity",
            
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      "state": "active",
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      "state": "active",
            
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      "vocabulary_id": null
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      "vocabulary_id": null
            
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    }
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    }
            
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  ],
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  ],
            
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  "title": "Increase Mitochondrial Dysfunction",
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  "title": "Increase Mitochondrial Dysfunction",
            
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  "toxin": [],
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  "toxin": [],
            
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  "type": "dataset",
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  "type": "dataset",
            
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  "url": "",
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  "url": "",
            
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  "version": "0.2"
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  "version": "0.2"
            
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}
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}