Mitochondrial complexes inhibition leading to heart failure via decreased ATP production

[Mitochondrial complexes inhibition leading to heart failure via decreased ATP production]

In accordance with the events outlined in the linear AOP framework for cardiotoxicity developed in the ALTERNATIVE project, we collected data from biological assays providing information on the potential toxic interactions between chemicals and specific biological targets.

List of assays considered to evaluate chemicals activity for Mitochondrial complexes inhibition: CCTE Simmons MITO basal resp rate OCR dn, CCTE Simmons MITO basal resp rate OCR up, CCTE Simmons MITO inhib resp rate OCR dn, CCTE Simmons MITO inhib resp rate OCR up, CCTE Simmons MITO max resp rate OCR dn, CCTE Simmons MITO max resp rate OCR up

Binary Endpoint: Mitochondrial complexes inhibition

AOP source: https://aopwiki.org/aops/480 Paper: https://doi.org/10.3390/toxics12010087