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Mitochondrial complexes inhibition leading to heart failure via decreased ATP...
[Mitochondrial complexes inhibition leading to heart failure via decreased ATP production] In accordance with the events outlined in the linear AOP framework for cardiotoxicity... -
hERG inhibition leading to cardiac toxicity
hERG channel blockade leading to sudden cardiac death Increased mortality triggered by drug-mediated blockade of human ether-a-gogo-related gene (hERG) channel. The inhibition... -
Increased myocardial oxidative stress
[Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress] In accordance with the events outlined in the linear... -
Increase Mitochondrial Dysfunction
Increase Mitochondrial Dysfunction In accordance with the events outlined in the linear AOP framework for cardiotoxicity developed in the ALTERNATIVE project, we collected data...
