6 datasets found

Organizations: IRFMN Formats: CSV

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  • Apical Cardiotoxicity

    Drug-induced cardiotoxicity (DICT). By utilizing labeling documents for FDA (U.S. Food and Drug Administration)-approved drugs, is developed the largest dataset of drugs...

  • Aryl Hydrocarbon Receptor Activation

    Aryl Hydrocarbon Receptor Activation Data: The Target ID (CHEMBL3201) is assigned to Aryl Hydrocarbon Receptor (AHR) activation, so we collected all data related to this...

  • Mitochondrial complexes inhibition leading to heart failure via decreased ATP...

    [Mitochondrial complexes inhibition leading to heart failure via decreased ATP production] In accordance with the events outlined in the linear AOP framework for cardiotoxicity...

  • hERG inhibition leading to cardiac toxicity

    hERG channel blockade leading to sudden cardiac death Increased mortality triggered by drug-mediated blockade of human ether-a-gogo-related gene (hERG) channel. The inhibition...

  • Increased myocardial oxidative stress

    [Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress] In accordance with the events outlined in the linear...

  • Increase Mitochondrial Dysfunction

    Increase Mitochondrial Dysfunction In accordance with the events outlined in the linear AOP framework for cardiotoxicity developed in the ALTERNATIVE project, we collected data...