Increased myocardial oxidative stress [Draft]

[Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress]

In accordance with the events outlined in the linear AOP framework for cardiotoxicity developed in ALTERNATIVE project we collected data from biological assays providing information on the potential toxic interactions between chemicals and specific biological targets.

List of assays considered for evaluating chemicals regarding Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress: APR HepG2 P-H2AX 24 h dn, APR HepG2 P-H2AX 24 h up, APR HepG2 P-H2AX 72 h dn, APR HepG2 P-H2AX 72 h up, APR HepG2 StressKinase 24 h dn, APR HepG2 StressKinase 24 h up, APR HepG2 StressKinase 72 h dn

AOP source: https://aopwiki.org/aops/479 paper: https://doi.org/10.3390/toxics12010087