Increase Mitochondrial Dysfunction [Draft]

Increase Mitochondrial Dysfunction

In accordance with the events outlined in the linear AOP framework for cardiotoxicity developed in the ALTERNATIVE project, we collected data from biological assays providing information on the potential toxic interactions between chemicals and specific biological targets. In this case the endpoint under consideration in the Mitochondrial Dysfunction.

Binary Endpoint.

List of the assays considered for evaluate mitochondrial dysfunction activity: APR HepG2 MitoMass 24 h dn, APR HepG2 MitoMass 24 h up, APR HepG2 MitoMass 72 h dn, APR HepG2 MitoMass 72 h up, APR HepG2 MitoMembPot 24 h dn, APR HepG2 MitoMembPot 24 h up, APR HepG2 MitoMembPot 72 h dn, APR HepG2 MitoMembPot 72 h up, ATG XTT Cytotoxicity up, TOX21 MMP ratio down, TOX21 MMP ratio up, TOX21 MMP rhodamine

AOP source: https://aopwiki.org/events/177

Data curation and data source: https://doi.org/10.3390/toxics12010087