Apical Cardiotoxicity

Drug-induced cardiotoxicity (DICT).

By utilizing labeling documents for FDA (U.S. Food and Drug Administration)-approved drugs, is developed the largest dataset of drugs annotated with ranked DICT risk in humans (DICTrank). DICTrank categorizes drugs into four categories of DICT concerns by integrating DICT severity and labeling content. The dataset consists of 1318 drugs, classified as follows: Most-DICTConcern (341), Less-DICT-Concern (528), No-DICT-Concern (343), and Ambiguous-DICTConcern (106; lacking sufficient information in the labeling document to determine cardiotoxicity potential).

Endpoint: Multilabel

Data source: https://doi.org/10.1101/2023.07.06.548029